Molecular genotyping for N-acetylation polymorphism in Japanese patients with colorectal cancer
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چکیده
منابع مشابه
Role of Molecular Biomarkers in Colorectal Cancer
Colorectal cancer (CRC) is amongst the most widespread cancers and is a most common cause of cancer associated mortality universally. Since previous decades, it has been cleared that CRC develops owing to the buildup of a series of genetic and epigenetic changes in the normal colonic epithelium. Regardless of the current development in surgery and therapies, overall survival of end stage CRC pa...
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Colorectal cancer (CRC) is one of the common causes of cancer death in Iranian population. Both genetic and epigenetic changes have been implicated in CRC pathogenesis. DACT2 gene as one of the WNT signaling pathway inhibitor was shown to display tumor suppressor activity in many cancers. The aim of present study was to investigate the methylation status of DACT2 gene and its ...
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By its frequency, colorectal cancer (CRC) has become a serious public health problem. BAT25 marker is included in the panel of five markers dedicated to the diagnosis of CCR microsatellite instability. The objective of this study was to evaluate the polymorphism and genetic diversity of the BAT25 marker in CRC cases in Senegal. This prospective study was performed on 22 CRC patients. After DNA ...
متن کاملAcetylation Polymorphism and Prevalence of Colorectal Adenomas1
Polymorphic W-acetyltransferase (NAT2), an enzyme present in the colon, may affect incidence of colon cancer. Individuals with NAT2 fast acetylator genotypes may have higher colon cancer risks due to faster conversion of certain carcinogens to mutagens. We determined NAT2 genotypes in 447 subjects with distal colon adenomas and in 487 controls. No significant increase in adenoma prevalence amon...
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INTRODUCTION Gene polymorphisms have a broad range of analysis, but are of particular use in molecular medicine due to their potential in revealing the genetic tendency in diseases such as cancer, heart attack etc. These studies basically depend on mutations that can be detected by proper techniques. The genes coding the insulin receptor substrate (IRS) proteins are among the most widely analys...
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ژورنال
عنوان ژورنال: Cancer
سال: 1994
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19941215)74:12<3108::aid-cncr2820741208>3.0.co;2-m